This is some Immunotherapy Of Mesothelioma U should know

Mesothelioma is a rare and heartbreaking form of cancer. Though there is no known cure, there are many forms of treatment that may be able to offer relief from the cancer's painful and debilitating symptoms; stop its spread; and, in some cases, help the body achieve remission.

One of the most difficult aspects of treating any cancer, including mesothelioma, is that the malignant cells, because they are not “germs” but are instead mutated body cells, have fooled the autoimmune system into treating them as if they’re normal, healthy cells. Immunotherapy is a form of treatment in which the doctor uses drugs, synthesized proteins, and antibodies to provoke the body’s autoimmune system into responding to the cancer cells as the malignancy they are. In clinical trials, immunotherapy has been shown as having the potential to stop the cancer's spread.

However, the battle against mesothelioma may be more complicated than with other forms of cancer, since it’s caused by the intake and embedding of tiny asbestos fibers into the lining of various body organs, such as the lungs, heart, reproductive organs, and abdomen. Malignant mesothelioma can metastasize to the brain, abdomen, and other organs. The actual cancer grows within the organ’s lining, which is what makes it such a tough cancer to fight, since its cellular base is different for each type of organ to which it attaches itself.

The chemicals used by oncologists for mesothelioma immunotherapy are called biological response modifiers (BRMs) and they work by unmasking the chemical camouflage behind which those cancerous cells are hiding. The body naturally produces BRMs, but sometimes in the case of a long siege of illness, the body doesn’t produces as many BRMs as are necessary. Scientists have replicated these BRMs so that doctors can increase their levels in patients fighting mesothelioma.

Some of the common BRM immunotherapies for mesothelioma are:

Interleukin2: A synthesized body protein which is, in its natural form, a normal part of the immune system. Administering this protein enhances the immune function.

Anti-angiogenics: These substances inhibit the blood flow to tumors by inhibiting the growth of blood vessels. Tumors need the nutrients in blood in order to grow.

Monoclonal Antibodies: Other synthesized body proteins, which, in their natural form, occur as part of the body’s defense system. These are the body’s warriors, which seek out unnatural cells and kill them.

Interferon: This was one of the original treatments in the immunotherapy arena. Interferon boosts the immune system, so that it will stop the growth and spread of the cancer cells.

When talking about the future of treatment with mesothelioma and immunotherapy, other areas of immunotherapy being studied are tumor cell vaccines; antigen vaccines; dendritic cell vaccines; vector-based vaccines; and DNA vaccines. Because of the complexity of mesothelioma, and the way it can attach to many different types of cells throughout the body, some of these treatments are created from the patient’s own blood or tumor cells, and are then used only in that patient. These types of treatments are, at this point in time, highly experimental.

It is often more successful to combine immunotherapy with other forms of treatment, attacking the cancer on multiple fronts. It is most often combined with chemotherapy or radiation therapy. Treatment is often self-administered in pill form, although sometimes injections are used. Side effects may include fatigue; nausea and vomiting; loss of appetite; fever; chills; low blood pressure; muscle aches; and bone pain. Currently immunotherapy is being studied in clinical trials and is not yet widely available.

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